樟树精油及其单体抗白色念珠菌活性及安全性研究

为探究樟树精油及其单体抗白色念珠菌活性及安全性,本研究通过纸片法和微量肉汤稀释法测定了樟树精油、葡萄柚精油、柠檬精油、薰衣草精油抗白色念珠菌活性,同时对樟树精油进行GC-MS挥发性成分鉴定,进一步分析樟树精油主要化学成分对白色念珠菌的抑菌活性,最后观察樟树精油及其单体对豚鼠皮肤刺激和小鼠血管收缩性影响.结果表明,樟树精...

Anti-Candida albicans Activity and Safety of Cinnamomum camphora Essential Oil and Its Components

To explore the anti-Candida albicans activity and safety of Cinnamomum camphora essential oil and its components,the anti-Candida albicans activity of Cinnamomum camphora essential oil that compared with grapefruit,lemon and lavender was determined by disk diffusion method and dilution method.Meanwhile,the GC-MS was used to detect the volatile components of essential oil.Moreover,the significant difference analysis among the chemical components and its correlation with anti-Candida acbicans activity were conducted.Finally,the Cinnamomum camphora essential oil and its components to stimulate the skin of guinea pigs and vascular permeability were observed.The results showed that the anti-Candida albicans activity of Cinnamomum camphora essential oil was stronger than that of grapefruit,lemon and lavender essential oil and it was mainly derived fromα-Terpineol,Terpinolene,α-Terpinene,Terpinen-4-ol,Sabinene,1,8-Eucalyptol.The skin of guinea pigs showed slight erythema after 5 days of continuous application of 4%Cinnamomum camphora essential oil,while 4%terpinen-4-ol showed slight erythema after 2 days of application.In addition,4%terpinene-4-ol could significantly increase the vascular permeability of mice.The results would provide a theoretical basis for the development and utilization of Cinnamomum camphora essential oil and the treatment of Candida albicans-related diseases.