Reproduction of antiviral effect in an in vivo model of human cytomegalovirus retinal infection |
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| Authors: | KA Laycock Y Kumano JS Pepose |
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| Affiliation: | Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St. Louis, MO 63110, USA. |
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| Abstract: | Fibroblast growth factors (FGFs) play important roles in a variety of developmental processes in mammals. The dependence of their activity on heparin binding has been a puzzle that, in recent years, has been the subject of active investigation. Recent structural analyses on complexes of FGFs with heparin fragments or heparin analogs have unveiled the extreme complexity of these systems. |
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