1. Unité de Nutrition Lipidique, INRA, 17 rue Sully’ BV 1540, 21034, Dijon, France 2. Faculté de Pharmacie, Dijon, France 3. Laboratoire de Recherche Sur les Ar?mes, INRA, Dijon, France
Abstract:
Two of the main classes of oxyphytosterols (7-keto and epoxides) were synthesized from sitosterol and campesterol and given to mesenteric duct-cannulated adult male rats. Lymph was collected during 24 h and was analyzed for oxysterols. The results showed that the lymphatic recovery of the phytosterol oxides was low: 4.7% of the given dose for epoxy derivatives and 1.5% for 7-keto compounds. The campesterol oxides presented a better absorption than the sitosterol oxides. During the process of absorption’ the epoxyphytostanols were also partly transformed in campestanetriol and stigmastanetriol.