Composite Colloidal Gels Made of Bisphosphonate‐Functionalized Gelatin and Bioactive Glass Particles for Regeneration of Osteoporotic Bone Defects |
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| Authors: | Mani Diba Winston A Camargo Mariateresa Brindisi Kambiz Farbod Alexey Klymov Stephan Schmidt Matthew J Harrington Lorenza Draghi Aldo R Boccaccini John A Jansen Jeroen J J P van den Beucken Sander C G Leeuwenburgh |
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| Affiliation: | 1. Department of Biomaterials, Radboud University Medical Center, EX Nijmegen, The Netherlands;2. Chemistry, Materials and Chemical Engineering Department “G. Natta,”, Politecnico di Milano, Milano, Italy;3. Institute of Organic and Macromolecular Chemistry, Heinrich‐Heine‐University Düsseldorf, Düsseldorf, Germany;4. Department of Biomaterials, Max Planck Institute for Colloids and Interfaces, Potsdam, Germany;5. Institute of Biomaterials, Department of Materials Science and Engineering, University of Erlangen–Nuremberg, Erlangen, Germany |
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| Abstract: | Injectable composite colloidal gels are developed for regeneration of osteoporotic bone defects through a bottom‐up assembly from bisphosphonate‐functionalized gelatin and bioactive glass particles. Upon bisphosphonate functionalization, gelatin nanoparticles show superior adhesion toward bioactive glass particles, resulting in elastic composite gels. By tuning their composition, these composite colloidal gels combine mechanical robustness with self‐healing ability. The composite colloidal gels support cell proliferation and differentiation in vitro without requiring any osteogenic supplement. In vivo evaluation of the composite colloidal gels reveals their capacity to support the regeneration of osteoporotic bone defects. Furthermore, the bisphosphonate modification of gelatin induces a therapeutic effect on the peri‐implantation region by enhancing the bone density of the osteoporotic bone tissue. Consequently, these composite colloidal gels offer new therapeutic opportunities for treatment of osteoporotic bone defects. |
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| Keywords: | biomedical applications colloids composite materials hydrogels self‐healing |
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