In Vivo Subcutaneous Thermal Video Recording by Supersensitive Infrared Nanothermometers |
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Authors: | Erving C. Ximendes Uéslen Rocha Tasso O. Sales Núria Fernández Francisco Sanz‐Rodríguez Inocencio R. Martín Carlos Jacinto Daniel Jaque |
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Affiliation: | 1. Grupo de Fot?nica e Fluidos Complexos, Instituto de Física, Universidade Federal de Alagoas, Maceió‐AL, Brazil;2. Fluorescence Imaging Group, Departamento de Física de Materiales, Facultad de Ciencias, Universidad Autónoma de Madrid, Madrid, Spain;3. Departamento de Fisiología, Facultad de Medicina, Universidad Autónoma de Madrid, Madrid, Spain;4. Instituo Ramon y Cajal de Investigacio Sanitaria (IRYCIS), Hospital Ramon y Cajal, Madrid, Spain;5. Departamento de Biología, Universidad Autónoma de Madrid, Madrid, Spain;6. Departamento de Física, Instituto de Materiales y Nanotecnología (IMN), Universidad de La Laguna, La Laguna, Tenerife, Spain |
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Abstract: | Some of the old and unrealizable dreams of biomedicine have become possible thanks to the appearance of novel advanced materials such as luminescent nanothermometers, nanoparticles capable of providing a contactless thermal reading through their light emission properties. Luminescent nanothermometers have already been demonstrated to be capable of in vivo subcutaneous punctual thermal reading but their real application as diagnosis tools still requires demonstrating their actual capacity for the acquisition of in vivo, time‐resolved subcutaneous thermal images. The transfer from 1D to 2D subcutaneous thermal sensing is blocked in the last years mainly due to the lack of high sensitivity luminescent nanothermometers operating in the infrared biological windows. This work demonstrates how core/shell engineering, in combination with selective rare earth doping, can be used to develop supersensitive infrared luminescent nanothermometers. Erbium, thulium, and ytterbium core–shell LaF3 nanoparticles, operating within the biological windows, provide thermal sensitivities as large as 5% °C?1. This “record” sensitivity has allowed for the final acquisition of subcutaneous thermal videos of a living animal. Subsequent analysis of thermal videos allows for an unequivocal determination of intrinsic properties of subcutaneous tissues, opening the venue to the development of novel thermal imaging‐based diagnosis tools. |
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Keywords: | biological windows nanoparticles subcutaneous thermal imaging thermal sensing |
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