In vivo whole-cell recording from neurons of the superior colliculus in fetal rats |
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Authors: | Y Sakata T Fujioka S Nakamura |
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Affiliation: | Department of Anesthesia, room S261, University of California, 513 Parnassus Avenue, San Francisco, CA 94143-0648, USA. bw@eleusis.ucsf.edu |
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Abstract: | The actions of halothane on serotonin-sensitive potassium channels (S K+ channels) were studied in sensory neurons of Aplysia. The normalized open probability of S K+ channels was increased by clinical concentrations of halothane in cell-attached and excised patches from neurons of the pleural ventrocaudal cluster. No voltage-dependence of channel activation by halothane was observed. Pre-treatment of neurons with 8-bromo-cAMP (8-Br-cAMP) or nordihydroguaiaretic acid (NDGA) had no effect on the relative level of channel activation by halothane. S K+ channels that were activated by arachidonic acid could also be activated by halothane and exhibited closely similar amplitude distributions of open channel current. Results from these experiments showed that S K+ channel activation by halothane did not depend on second messenger modulation of channel activity. We conclude that it is likely that halothane directly activates S K+ channels. |
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