| 4-[2-羟基-3-(1H-咪唑基-1)丙氧基]-3-甲氧基苯甲酸及其类似物的合成 |
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| 引用本文： | 张恩立,周鹏,李家明,何勇,袁明,许勤龙.4-[2-羟基-3-(1H-咪唑基-1)丙氧基]-3-甲氧基苯甲酸及其类似物的合成[J].上海化工,2012,37(9):14-16. |
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| 作者姓名： | 张恩立 周鹏 李家明 何勇 袁明 许勤龙 |
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| 作者单位： | 安徽中医学院药学院安徽省现代中药重点实验室,安徽合肥,230031 |
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| 基金项目： | 安徽省高校自然基金重点项目 |
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| 摘 要： | 以芳酸酯为起始原料,经Williamson醚化、亲核取代和水解反应,合成4-2-羟基-3-(1H-咪唑基-1)丙氧基]-3-甲氧基苯甲酸及其3个类似物(3c~3f)。所合成的目标化合物均未见文献报道,其结构经IR、1H-NMR、13C-NMR及MS确证。所设计的合成方法简单易行。
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| 关 键 词： | 咪唑 化学合成 抗血小板聚集 |
Synthesis of 4-(2-hydroxy-3-(1H-imidazol-1-yl) propoxy)-3-methoxy Benzoic Acid and Its Analogues |
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| Zhang Enli Zhou Peng Li Jiaming He Yong Yuan Ming Xu Qinlong.Synthesis of 4-(2-hydroxy-3-(1H-imidazol-1-yl) propoxy)-3-methoxy Benzoic Acid and Its Analogues[J].Shanghai Chemical Industry,2012,37(9):14-16. |
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| Authors: | Zhang Enli Zhou Peng Li Jiaming He Yong Yuan Ming Xu Qinlong |
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| Affiliation: | Zhang Enli Zhou Peng Li Jiaming He Yong Yuan Ming Xu Qinlong |
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| Abstract: | The 4-（2-hydmxy-3-（1H-imidazol-1-yl） propoxy）-3-methoxy benzoic acid and its analogues （3c-3f） were synthesized from aryl esters via Williamson etherification, nucleophilic Substitution and hydroxylation. The target eompounds synthesized had not been reported in literatures, and their Chemical structures were confirmed by IR, 1H-NMR, 13C-NMR and MS. The results showed that the synthetic method was simple and feasible. |
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| Keywords: | Imidazole Synthesis Antiplatelet aggregation |
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