| 基于硼氢化钾-三氟化硼乙醚还原体系的3,4-二甲氧基苯乙胺合成新方法 |
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| 引用本文： | 李定中,蔡安安,魏建科,游懿,龚福春.基于硼氢化钾-三氟化硼乙醚还原体系的3,4-二甲氧基苯乙胺合成新方法[J].广东化工,2010,37(2):19-20. |
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| 作者姓名： | 李定中 蔡安安 魏建科 游懿 龚福春 |
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| 作者单位： | 长沙理工大学,化学与生物工程学院,湖南,长沙,410004 |
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| 基金项目： | 湖南省科技计划资助项目(2009CK3069) |
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| 摘 要： | 以邻苯二酚为原料,经醚化、Vilsmeier反应制得藜芦醛,收率95.2%,藜芦醛与硝基甲烷反应制得了3,4-二甲氧基苯基-β-硝基乙烯,收率高达93.6%,然后利用硼氢化钾-三氟化硼乙醚体系(KBH4/BF3-Et2O)催化还原3,4-二甲氧基苯基-β-硝基乙烯合成3,4-二甲氧基苯乙胺。该方法使用KBH4/F3B-Et2O还原体系,具有反应条件温和、后处理容易、产率较高等特点,适于工业化生产。
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| 关 键 词： | KBH4/BF3-Et2O体系 3 4-二甲氧基苯乙胺 还原 |
Synthesis of 3,4-Dimethoxy Phenethylamine Based on KBH4/F3B-Et2O Reduction System |
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| Li Dingzhong,Cai Anan,Wei JianKe,You Yi,Gong Fuchun.Synthesis of 3,4-Dimethoxy Phenethylamine Based on KBH4/F3B-Et2O Reduction System[J].Guangdong Chemical Industry,2010,37(2):19-20. |
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| Authors: | Li Dingzhong Cai Anan Wei JianKe You Yi Gong Fuchun |
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| Affiliation: | (College of Chemistry and Biological Engineering, Changsha University of Science and Technology, Changsha 410004, China) |
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| Abstract: | Veratraldehyde was prepared from pyrocatechol by methylation and vilsmeier reaction with a yield of 95.2 %.3,4-dimethoxyphenethylamine was synthesized from veratraldehyde by reaction with nitromethane and reduction with KBH4/BF3-Et2O system in two steps.The reaction was not only condition-facile and easy to dealing with product,but also plurinatality.So the process can be used in the industry. |
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| Keywords: | KBH4/F3B-Et2O 3 4-dimethoxyphenethylamine reduction |
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