复凝聚法制备白术挥发油微胶囊及表征

以白术挥发油为芯材,壳聚糖和海藻酸钠为壁材,采用复凝聚法制备微胶囊,通过单因素实验研究工艺参数对挥发油包埋率的影响,采用激光粒度分析仪、扫描电镜(SEM)、傅里叶变换红外光谱(FT-IR)、热重分析仪(TG-DTA)对微胶囊的粒径分布、表面形貌、化学结构、芯材含量进行表征。结果表明:在芯壁比为1∶2,乳化剂用量为5%,复凝聚温度为40℃,壳聚糖质量分数为1%,海藻酸钠质量分数为2%,pH 1.5,乳化转速6 000 r/min条件下制备的微胶囊包埋效果最好。微胶囊颗粒大致呈球状,表面结构致密,无明显的裂缝和洞孔,包埋率高,热稳定性能好,研究结果可为白术挥发油微胶囊的制备、鉴定、质量控制和制剂学性质的研究提供依据。

Study on Preparation and Characterization of Atractylodes Macrocephala volatile oil Microcapsules by Complex Coagulation Method

The microcapsules, using volatile oil of Atractylodes macrocephala as core material and chitosan and sodium alginate as wall material, were prepared by complex coacervation method. The effects of process parameters on the embedding rate of volatile oil were studied by single factor experiments. The particle size distribution, surface morphology, chemistry structure , and core material content of microcapsules were characterized by laser particle size analyzer, SEM, FT-IR and TG-DTA. The results showed that the microcapsules prepared under the conditions of core-wall ratio of 1:2, emulsifier dosage of 5%, Coacervation temperature of 40 °C, chitosan mass fraction of 1%, sodium alginate mass fraction of 2%, pH of 1.5 and emulsifying speed of 6000 r/min had the best embedding effect. The microcapsule particles are spherical in shape, with compact surface structure, no obvious cracks and holes, high embedding rate and good thermal stability. The results can provide a basis for the preparation, identification, quality control and pharmacological properties of Atractylodes macrocephala volatile oil microcapsules.