Cholesterol synthesis and degradation in normal rats fed a cholesterol-free diet with excess cystine |
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Authors: | Yoritaka Aoyama Nobuyuki Amano Akira Yoshida |
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Affiliation: | (1) Department of Applied Biological Chemistry’ School of Agricultural Sciences, Nagoya University, 464-8601 Nagoya, Japan;(2) Division of Applied Bioscience’ Graduate School of Agriculture, Hokkaido University, Nishi-9’ Kita-9’ Kita-ku, 060-8589 Sapporo, Japan |
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Abstract: | Feeding a diet with excess cystine to rats resulted in hypercholesterolemia. To understand the mechanism of the hypercholesterolemia’
cholesterol synthesis and degradation’ bile acid content of bile’ and fecal steroids were determined. The in vivo incorporation of tritiated water into hepatic cholesterol’ and activity of hepatic 3-hydroxy-3-methylglutaryl-CoA reductase
in rats fed a high-cystine diet were significantly higher than those in rats fed a control diet. The activity of hepatic cholesterol
7α-hydroxylase was similar between two groups. Little effect of cystine supplementation was found on fecal sterol excretion
although there were some changes in biliary excretion of cholic acid derivatives. These results indicate that hypercholesterolemia
caused by feeding of a high-cystine diet may be due to the stimulation of hepatic cholesterol synthesis. |
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