Hydroxyapatite-based nanoparticles as a coating material for the dentine surface: An antibacterial and toxicological effect |
| |
| Affiliation: | 1. Department of Chemistry, Ankara University, 06100 Ankara, Turkey;2. Department of Biology, Gazi University, 06500 Ankara, Turkey;3. Department of Bioengineering, Kırıkkale University, 71450 Yahşihan-Kırıkkale, Turkey;4. Department of Physics, Hacettepe University, 06800 Beytepe, Ankara, Turkey;1. School of Materials Science and Nanotechnology, Jadavpur University, Kolkata 700032, India;2. Department of Veterinary Surgery and Radiology, West Bengal University of Animal and Fishery Sciences, Kolkata 700037, India;3. Bioceramics and Coating Division, CSIR-Central Glass and Ceramic Research Institute, Kolkata 700032, India;4. Department of Mechanical Engineering, Jadavpur University, Kolkata 700032, India;5. Department of Veterinary Physiology, West Bengal University of Animal and Fishery Sciences, Kolkata 700037, India;1. Department of Engineering Physics, Faculty of Engineering, Ankara University, 06100 Beşevler-Ankara, Turkey;2. Institute of Nuclear Sciences, Ankara University, 06100 Beşevler-Ankara, Turkey;1. Department of Chemistry, Faculty of Arts and Sciences, Kırıkkale University, Kırıkkale, Turkey;2. Department of Bioengineering, Faculty of Engineering, Kırıkkale University, Kırıkkale, Turkey;1. Department of Biotechnology, Koneru Lakshmaiah Education Foundation, Vaddeswaram, Guntur, Andhra Pradesh 522502, India;2. Department of Chemistry, Chaudhary Ranbir Singh University, Jind, Haryana 126102, India |
| |
| Abstract: | In this study, nano sized hydroxyapatite (nHAp) and Ag(I) doped hydroxyapatite (Ag-nHAp) particles were synthesized by the precipitation method and used as a coating material for remineralization on caries-affected dentine samples. Characterization studies of both the synthesized hydroxyapatite-based particles and the coated dentine samples were performed using instrumental techniques such as SEM and FTIR, and then toxicity and antibacterial properties were also evaluated. It was observed that dentine samples were effectively coated by both nHAp and Ag-nHAp particles which have no toxic effects. Furthermore, the coating of nano-hydroxyapatite on dentine samples positively contributed to the viability of L929 fibroblast cells and also provided an antibacterial effect against to bacteria such as S. mutants, C. albicans and E. coli bacteria that are most frequently caused caries in the teeth. While all type of bacteria was eliminated by the nHAp coated dentine samples at 24th, Ag-nHAp coated dentine samples removed to all bacteria type at 1st. |
| |
| Keywords: | Dentine coating Nanoparticles Hydroxyapatite Silver Antibacterial Cytotoxicity |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
