| 酰化反应合成N-(2-溴-4-甲氧基苯基)丙烯酰胺的研究 |
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| 引用本文： | 袁加程.酰化反应合成N-(2-溴-4-甲氧基苯基)丙烯酰胺的研究[J].化学世界,2012,53(12). |
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| 作者姓名： | 袁加程 |
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| 作者单位： | 江苏食品职业技术学院生物与化学工程学院,江苏淮安,223003 |
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| 基金项目： | 淮安市科技支撑计划项目 |
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| 摘 要： | 研究了2-溴-4-甲氧基苯胺与丙烯酰氯发生酰化反应合成了N-(2-溴-4-甲氧基苯基)丙烯酰胺的方法。以95.7%的收率得到N-(2-溴-4-甲氧基苯基)丙烯酰胺。探讨了反应物物质的量比、反应时间、反应温度和碱的添加对酰化反应的影响。该方法原料易得,反应条件易于控制,收率高,对环境友好。
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| 关 键 词： | N-(2-溴-4-甲氧基苯基)丙烯酰胺 2-溴-4-甲氧基苯胺 酰化 |
Synthesis of N-(2-Bromo-4-methoxyphenyl)acrylamide by Acylation |
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| Abstract: | A method for synthesis of N-(2-bromo-4-methoxyphenyl)acrylamide by acylation was introduced.N-(2-Bromo-4-methoxyphenyl)acrylamide was obtained by the acylation of 2-bromo-4-methoxyaniline with acryloyl chloride in 95.7% yield.The effect of molar ratio of reactants,reaction temperature,reaction time and the addition of alkali on the acylation reaction was studied.The new procedure for preparing N-(2-bromo-4-methoxyphenyl)acrylamide has the advantages of easy source of material,good yield,simple operation and environmental benignity. |
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| Keywords: | N-(2-bromo-4-methoxyphenyl)acrylamide 2-bromo-4-methoxyaniline acylation |
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