| 乙亚氨酸乙酯盐酸盐的制备新工艺研究 |
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| 引用本文： | 陆雪良. 乙亚氨酸乙酯盐酸盐的制备新工艺研究[J]. 应用化工, 2003, 32(3): 21-23 |
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| 作者姓名： | 陆雪良 |
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| 作者单位： | 常熟高等专科学校,应用化学研究所,江苏,常熟,215500 |
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| 摘 要： | 介绍了以乙腈、乙醇、甲苯、硫酸和盐酸为原料,制备医药维生素B1中间体乙亚氨酸乙酯盐酸盐的新工艺。优化工艺条件为:乙腈13 2g、乙醇20g、甲苯23g、硫酸83g、盐酸56g,反应温度(28±1)℃,反应时间为14～16h。乙亚氨酸乙酯盐酸盐的产率≥95%。
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| 关 键 词： | 乙亚氨酸乙酯盐酸盐 维生素B1 乙腈 氯化氢 新工艺 |
| 文章编号： | 1671-3206(2003)03-0021-03 |
| 修稿时间： | 2002-11-26 |
A new process for preparation of acetimidoyl ethyl ether hydrochloride |
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| Abstract: | A new process for the preparation of acetimidoyl ethyl ether hydrochloride which is used as intermediate for vitamin B1 from acetonitrile,alcohol,toluene,sulfuric acid and chlorhydric acid was introduced. The optimum reaction conditions were:acetonitrile 13.2 g,alcohol 20 g,toluene 23 g,sulfuric acid 83 g,chlorhydric acid 56 g,reaction at (28±1)℃ for 14～ 16 h.The title compound acetimidoyl ethyl ether hydrochloride was obtained in ≥95% yield. |
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| Keywords: | acetimidoyl ethyl ether hydrochloride vitamin B_1 acetonitrile chlorine hydride new process |
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