The interaction of local anesthetics with lipid membranes |
| |
| Affiliation: | 1. Shandong Provincial Key Laboratory of UHV Transmission Technology and Equipment, School of Electrical Engineering, Shandong University, Jinan 250061, China;2. School of Physics, Shandong University, Jinan 250061, China;1. Faculty of Environmental Sciences, Czech University of Life Sciences, Prague, Czech Republic;2. University of Chemistry and Technology, Prague, Czech Republic |
| |
| Abstract: | Molecular Dynamic Simulations are performed to evaluate the interaction of lidocaine, procaine and tetracaine with a lipid membrane. The main interest is to evaluate the structural changes produced by these local anesthetics in the bilayers. Penetration trajectories, interaction energies, entropy changes and an order parameter are calculated to quantify the destabilization of the lipid configurations. We show that such structural parameters give important information to understand how anesthetic agents influence the structure of plasma membranes. Graphic processing units (GPUs) are used in our simulations. |
| |
| Keywords: | Molecular Dynamic Simulations Lipid membrane Local anesthetics |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
