Identification of arg-30 as the essential residue for the enzymatic activity of Taiwan cobra phospholipase A2 |
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Authors: | LS Chang SR Lin CC Chang |
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Affiliation: | Department of Biochemistry, Kaohsiung Medical College, Kaohsiung, Taiwan. lschang@mail.nsysu.edu.tw |
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Abstract: | Three cohorts of patients with the factor V Leiden mutation were recruited independently (heterozygotes, homozygotes and combined thrombophilia). The antithrombotic efficacy of oral anticoagulation and the predictive value for recurrence of an idiopathic as opposed to a precipitated first event were determined. Idiopathic first events occurred at an older age than precipitated events (43 v 26 years, LR = 23.31, P < 0.001). None of the patients had a recurrent event while on warfarin but the median time to recurrence after stopping warfarin was 9 years (95% CI 0.7-17.3 years). The time to recurrence was shorter when the first event was idiopathic as opposed to precipitated (3.5 v 13 years, LR = 4.76, P = 0.029). A calculation of benefit to risk of oral anticoagulation with a target INR of 2.5 does not support the use of long-term therapy in all patients with the factor V Leiden mutation following a first thrombotic event. |
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