Integrin-mediated signalling of gelatinase B secretion in colon cancer cells |
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Authors: | J Niu X Gu J Turton C Meldrum EW Howard M Agrez |
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Affiliation: | Discipline of Surgical Science, Faculty of Medicine and Health Sciences, University of Newcastle, New South Wales, Australia. |
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Abstract: | The progression of colon cancer has been linked to both cell adhesion molecules called integrins and matrix-degrading enzymes called metalloproteinases. Herein we report that the alpha v beta 6 integrin expressed in colon cancer cells induces gelatinase B secretion through the C-terminal cytoplasmic extension unique to the beta 6 integrin subunit, and that this ligand-independent event involves activation of the protein-kinase-C pathway. |
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