| 手性a-氰基丙烯酸酯类化合物的合成及生物活性研究 |
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| 引用本文： | 张慧苹,姜琳琳. 手性a-氰基丙烯酸酯类化合物的合成及生物活性研究[J]. 湖北化工, 2012, 0(10): 51-53 |
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| 作者姓名： | 张慧苹 姜琳琳 |
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| 作者单位： | 济宁学院化学与化工系,山东济宁273115 |
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| 基金项目： | 济宁学院青年科研基金项目（2011QNKJ11） |
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| 摘 要： | a-氰基丙烯酸酯类化合物是一类抑制植物光合作用PSⅡ的重要除草荆，引入手性因素可以提高其活性。以氰基乙酸乙酯为原料，合成了a-对三氟甲基苯胺-3-（R／S）-a-甲基苄胺-2-氰基丙烯酸酯，对中间体及目标化合物进行了结构表征；并对a-氰基丙烯酸酯类化合物的生物活性进行了研究。结果表明，该类化合物除草活性不突出，但具有一定的抗烟草花叶病毒活性及抗癌活性，具有深入研究的价值。
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| 关 键 词： | a-氰基丙烯酸酯 手性 反应机理 生物活性 |
Study on Synthesis and Bioactivity of Chiral a-Cyanoacrylate Compounds |
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| ZHANG Hui-ping,JIANG Lin-lin. Study on Synthesis and Bioactivity of Chiral a-Cyanoacrylate Compounds[J]. Hubei Chemical Industry, 2012, 0(10): 51-53 |
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| Authors: | ZHANG Hui-ping JIANG Lin-lin |
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| Affiliation: | (College of Chemistry and Chemical Engineering , J ining University , J ining 273115 ,China) |
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| Abstract: | a-Cyanoacrylate is a kind of important herbicide targeted in photosystem PSⅡ. Introduction ot chiral factor can improve its activity. Using cyano ethyl acetate as raw material, ethyl 3-（R/S）-l-phenylethyl- amino-3-（4-（trifluoromethyl）-phenylamino）-2-cyanoacrylate were synthesized. The intermediates and the target compounds were characterized, and the bioactivities of chiral a-cyanoacrylate compounds were determined. The results showed that herbicidal activity of chiral a-cyanoacrylate compounds were not prominent,but they had a certain resistance activity to tobacco mosair virus and anti-cancer activity. |
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| Keywords: | a-cyanoacrylate chirality reaction mechanism bioactivity |
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