| 正交设计法催化合成苯基甘氨酸 |
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| 引用本文： | 项生昌,赵崇涛,翁家宝,朱则善. 正交设计法催化合成苯基甘氨酸[J]. 化学世界, 2000, 41(1): 30-33 |
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| 作者姓名： | 项生昌 赵崇涛 翁家宝 朱则善 |
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| 作者单位： | 福建师范大学化学系,福建,福州,350007 |
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| 基金项目： | 福建省自然科学基金，B97009， |
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| 摘 要： | 以苯甲醛、氯仿、氢氧化钾和氨水为原料，在相转移催化剂（ＰＴＣ）和β－环糊精（β－ＣＤ）混合催化剂存在下一锅合成了苯基甘氨酸。采用正交设计方法考察了底物、试剂用量、溶剂等对反应的影响，收率达９５．６％
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| 关 键 词： | 苯基甘氨酸 β-环糊精 相转移催化剂 正交设计方法 |
Synthesis of Phenylglycine by Using Orthogonal Design Test |
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| XIANG Sheng-chang,ZHAO Chong-tao,WEN Jia-bao,ZHU Ze-shan. Synthesis of Phenylglycine by Using Orthogonal Design Test[J]. Chemical World, 2000, 41(1): 30-33 |
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| Authors: | XIANG Sheng-chang ZHAO Chong-tao WEN Jia-bao ZHU Ze-shan |
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| Abstract: | In the presence of PTC and β cyclodextrin ( β CD) binary catalyst system, DL α amino α phenylacetic acid was synthesized in one pot from benzaldehyde, potassium hydroxide, ammonia and chloroform. The conditions were optimized by orthogonal design, the best result, 95.6% yield was obtained. |
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| Keywords: | phenylglycine β-cyclodextrin phase transfer catalyst orthogonal design test |
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