Genetic immunization with adeno-associated virus vectors expressing herpes simplex virus type 2 glycoproteins B and D |
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| Authors: | WC Manning X Paliard S Zhou M Pat Bland AY Lee K Hong CM Walker JA Escobedo V Dwarki |
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| Affiliation: | Chiron Corporation, Emeryville, California 94608, USA. william_manning@cc.chiron.com |
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| Abstract: | Intramuscular injection of mice with an adeno-associated virus (AAV) vector expressing herpes simplex virus type 2 glycoprotein B led to the generation of both gB-specific major histocompatibility complex class I-restricted cytotoxic T lymphocytes and anti-gB antibody. AAV-mediated immunization was more potent than plasmid DNA or protein in generating antibody responses. |
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