Action of three bile acids on hepatic and intestinal cholesterogenesis in the rat |
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Authors: | M O Reynier CH Marteau J L Vigne A Mule C Crotte A Gerolami |
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Affiliation: | (1) Unité de Recherches de Pathologie Digestive, U 31 INSERM 46, chemin de la Gaye, 13009 Marseille, France;(2) Institut National de la Santé et de la Racherche Médicale INSERM U 31, 46, chemin de la Gaye, 13009 Marseille, France |
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Abstract: | Incorporation of 114−C] acetate into cholesterol by subcellular particles from the liver and the small intestine of rats with a biliary diversion
and a duodenal perfusion of sodium taurocholate, taurochenodeoxycholate or taurodehydrocholate, was studied in vitro. In the
liver, taurochenodeoxycholate prevented the increase of cholesterol synthesis induced by biliary drainage. Taurocholate had
no action on cholesterol synthesis at any time, day or night. Intestinal synthesis of cholesterol was reduced by taurocholate
and taurochenodeoxycholate but was not modified by taurodehydrocholate infusion. |
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