GC rich DNA oligonucleotides with narrow minor groove width |
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| Authors: | RH Sarma MH Sarma L Dai K Umemoto |
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| Affiliation: | Institute of Biomolecular Stereodynamics, Chemistry, State University of New York at Albany, 12222, USA. rhs07@cnsvax.albany.edu |
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| Abstract: | Investigation of the width of the minor groove using 500 MHz NMR spectroscopy in three closely related 11-mer B-DNA duplexes shows that the minor groove is narrow in a GC rich oligonucleotide, and that a narrow minor groove is not something endemic to DNAs with persistent repetitions of adenine nucleotides (A-tract DNA). The width of the groove is dictated by local sequence contexts and independent of neighboring A-tract DNA. |
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