| 聚乳酸微球的制备工艺研究 |
| |
| 引用本文： | 陆荣,郑雪芹,董锐.聚乳酸微球的制备工艺研究[J].化工技术与开发,2009,38(3). |
| |
| 作者姓名： | 陆荣 郑雪芹 董锐 |
| |
| 作者单位： | 1. 盐城工学院材料工程学院,江苏,盐城,224003
2. 盐城工学院实验教学部,江苏,盐城,224003 |
| |
| 基金项目： | 江苏省生态环境材料重点实验室重点学科建设开放基金 |
| |
| 摘 要： | 以聚乳酸为基础材料,选择聚乙烯醇为乳化剂,采用O/W乳化-溶剂挥发法制备形态较好的聚乳酸微球.在可确定因素固定下来后,在保证成球质量的基础上,分别通过调节乳化剂的浓度和其它因素在一定范围内来控制微球的平均粒径.单因素实验结果表明,PLA浓度、乳化剂浓度、搅拌速度、滴加速度对微球性能影响显著.通过正交实验得出制备粒径大小为100 μm左右聚乳酸微球的最佳工艺方案为:搅拌速度600 r·min-1,PLA浓度9%(g·mL-1),PVA浓度0.5%(g·mL-1),滴加速度1.5 mL·min-1.
|
| 关 键 词： | 聚乳酸 微球 制备 正交设计 |
Preparation Research of PLA Microspheres |
| |
| LU Rong,ZHEN Xue-Qin,DONG Rui.Preparation Research of PLA Microspheres[J].Technology & Development of Chemical Industry,2009,38(3). |
| |
| Authors: | LU Rong ZHEN Xue-Qin DONG Rui |
| |
| Affiliation: | 1.School of Materials Engineering;Yancheng Institute of Technology;Yancheng 224003;China;2.Department of Experiment Teaching;China |
| |
| Abstract: | Polylactic acid(PLA) microspheres were prepared by O/W emulsion/solvent evaporation method applied PLA as foundation material and polyvinyl alcohol as emulsifier.On the basis of assuring the quality of produced particles,the concentration of emulsifier and other factors in a certain range were adjusted to control the average particle size of microspheres after fixed the confirmable factors.Single factor experiment results showed that there were four factors significantly affected the performance of the micr... |
| |
| Keywords: | |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
|
