Inhibition of mammary tumor growth using lysyl oxidase-targeting nanoparticles to modify extracellular matrix |
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| Authors: | Kanapathipillai Mathumai Mammoto Akiko Mammoto Tadanori Kang Joo H Jiang Elisabeth Ghosh Kaustabh Korin Netanel Gibbs Ashley Mannix Robert Ingber Donald E |
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| Affiliation: | Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, Massachusetts 02115, United States. |
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| Abstract: | A cancer nanotherapeutic has been developed that targets the extracellular matrix (ECM)-modifying enzyme lysyl oxidase (LOX) and alters the ECM structure. Poly(d,l-lactide-co-glycolide) nanoparticles (～220 nm) coated with a LOX inhibitory antibody bind to ECM and suppress mammary cancer cell growth and invasion in vitro as well as tumor expansion in vivo, with greater efficiency than soluble anti-LOX antibody. This nanomaterials approach opens a new path for treating cancer with higher efficacy and decreased side effects. |
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