Catechol-O-methyltransferase genotype and susceptibility to Parkinson's disease in Japan. Short communication |
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Authors: | A Yoritaka N Hattori H Yoshino Y Mizuno |
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Affiliation: | Department of Neurology, Juntendo University School of Medicine, Tokyo, Japan. |
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Abstract: | We report -108Met/Val polymorphism of the COMT gene in Japanese patients with Parkinson's disease (PD). The allele frequency for -108Val was higher in PD patients compared with controls, although the differences did not reach the statistical significance. However, the frequency of -108Val homozygotes was significantly higher in PD patients (56.8%) than in control subjects (44.2%), and heterozygotes of -108Met/Val were less in PD. COMT gene polymorphism may constitute a genetic risk factor for PD among Japanese. |
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