[1—^14C]—己酰乙醛亚硫酸氢钠药代动力学研究

A study on the pharmacokinetics of [l-~(14)C]-hexanoyl aldehyde sodium bisulfite (~(14)C-HASB) in mice

After a single intravenous injection of 1-14C]-hexanoyl aldehyde sodium bisulfite (HASB), the blood radioactivity time course curve fitted well a two-compartment open model. The radioactivity distributed widely in the body, with the concentrations in liver and kidneys markedly higher than in blood and other tissues. Except in kidneys and liver, the radioactivities in tissues decreased to quite low levels 4h after administration. The ra dioactivity in tumors were relatively low. Thin layer chromatographic (TLC) analyses indi-cated that most of radioactivity in serum was in the form of unchanged 14C-HASB and the drug was metabolized rapidly after passing into some tissue cells in vivo. The major routes of elimination were found to be via expiration with 26.76% of the 14C recovered as carbon dioxide in 3h and via urine with 14.6% of the 14C recovered in 24h mainly in the form of metabolites.