哈萨克族传统发酵乳酪的乳清对实验性动脉粥样硬化大鼠的作用

观察哈萨克族传统发酵乳酪的乳清(简称乳酪乳清)对实验性动脉粥样硬化大鼠的作用。健康SD大鼠40只随机分为5组:正常组(n=8),髙脂模型组(n=8),阳性对照组(n=8)及给药组(n=16)。通过高脂饮食4周及内皮损伤建立动脉粥样硬化大鼠模型,给予哈萨克族传统发酵乳酪的乳清(大、小剂量组)及阳性对照药辛伐他汀3周后,分别测定肝指数(肝重/体重)、血脂、肝脂、C-反应蛋白等指标,并对大鼠冠状动脉,主动脉病理形态学进行观察。结果表明,乳酪乳清0.5mg/100g和1mg/100g组及辛伐他汀组(0.5mg/100g)降低动脉粥样硬化大鼠血清胆固醇(TC)分别为30.9%(P<0.01)及19%(P<0.05)。低密度脂蛋白胆固醇(LDL-C)分别降低17.3%(P<0.05)及31.3%(P<0.01)。模型组与给药组和辛伐他组相比,C反应蛋白显著降低(P<0.01)。病理切片结果表明,乳酪乳清能明显减轻大鼠动脉粥样硬化性损伤。结论:乳酪乳清0.5mg/100g组和1mg/100g组均具有调血脂作用,提示乳酪乳清具有显著抗大鼠实验性动脉粥样硬化作用。

Effects of traditional fermention cheese whey on experimental atherosclerosis in rats

Object To study the effect of chess whey which is a kind of Kazakh medicine on experimental atherosclerotic formation in rats. Methods:40 rats randomly divided into 5 groups :normal group,control group,model group and dosage groups. By using high fat diet and injury of endothelial cells establish a arteriosclerosis in rats. after that comparatively observe plasma,blood vessel actives and C-reaction protein .Results: Serum total cholesterol,low density lipoprotein cholesterol,triglyceride in plasma decreased compared with those of model group .Conclusion chess whey had antiatherogenic properties.