High-temperature chemical and microstructural transformations of an organic-inorganic nanohybrid captopril intercalated Mg-Al layered double hydroxide |
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Authors: | Hui Zhang Shao-Huan Guo Kang Zou Xue Duan |
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Affiliation: | State Key Laboratory of Chemical Resource Engineering, Beijing University of Chemical Technology, Box 98, Beijing 100029, China |
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Abstract: | The thermal evolution of a crystalline organic-inorganic nanohybrid captopril intercalated Mg-Al layered double hydroxide (LDH) [Mg0.68Al0.32(OH)2] (C9H13NO3S)0.130(CO3)0.030·0.53H2O obtained by coprecipitation method is studied based upon in situ high-temperature X-ray diffraction, in situ infrared and thermogravimetric analysis coupled with mass spectroscopy analysis. The results reveal that a metastable quasi-interstratified layered nanohybrid involving carbonate-LDH and reoriented less ordered captopril-LDH was firstly observed as captopril-LDH heat-treated between 140 and 230 °C. The major decomposition/combustion of interlayer organics occur between 270 and 550 °C. A schematic model on chemical and microstructural evolution of this particular drug-inorganic nanohybrid upon heating in air atmosphere is proposed. |
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Keywords: | A. Layered compounds C. X-ray diffraction C. Infrared spectroscopy C. Thermogravimetric analysis (TGA) D. Microstructure |
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