| 丝氨酸铂配合物的合成、表征及抗肿瘤活性初探 |
| |
| 引用本文： | 刘京萍,李金. 丝氨酸铂配合物的合成、表征及抗肿瘤活性初探[J]. 化学世界, 2009, 50(9) |
| |
| 作者姓名： | 刘京萍 李金 |
| |
| 作者单位： | 北京联合大学师范学院应用生物系,北京,100011 |
| |
| 基金项目： | 北京市教委科技发展基金 |
| |
| 摘 要： | 用二碘二氨合铂与L-丝氨酸在水溶液中合成了丝氨酸铂配合物。通过薄层色谱、差动热分析、红外光谱、元素分析对丝氨酸铂配合物进行了初步表征。利用MTT体外检测法初步体外抗癌活性实验结果表明:L-丝氨酸铂配合物对人体的宫颈癌细胞(Hela)和胃癌细胞株(BGC-823)生长有明显抑制作用。
|
| 关 键 词： | 铂配合物 二碘二氨合铂 抗癌活性 合成 |
The Synthesis and Characterization of L-serine Platinum Complex and an Elementary Exploration of Its Anti-cancer Effects |
| |
| LIU Jing-ping,LI Jin. The Synthesis and Characterization of L-serine Platinum Complex and an Elementary Exploration of Its Anti-cancer Effects[J]. Chemical World, 2009, 50(9) |
| |
| Authors: | LIU Jing-ping LI Jin |
| |
| Affiliation: | Normal College of Beijing Union University;Beijing 100011;China |
| |
| Abstract: | The L-serine platinum complex was synthesized from iodine-platinum diamine(Pt(NH_3)_2I_2) and L-serine in aqueous solution.The L-serine platinum complex was characterized by TLC,DSC,IR spectroscopy and elemental analysis,and the anticancer activity was measured by external body test.The results indicated that the platinum complex bore obvious anticancer effects to Hela and inhibitory effects to the growth of BGC-823. |
| |
| Keywords: | platinum complex iodine-platinum diamine anticancer activity synthesis |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
