The influence of selenium and neuroleptics on the rat brain nuclear regulatory mechanism in carcinogenesis |
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Authors: | H Loncar-Stevanovi? Z Vujovi? A Drazi? D Lazi? S Jakuli? T Jovanovi? |
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Affiliation: | Division of Biology, Kansas State University, Manhattan 66506, USA. |
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Abstract: | alpha-Crystallins possess molecular chaperone properties and are one of the most abundant of the lenticular proteins. Posttranslational modifications of these proteins have been implicated as a possible etiology of human cataracts. This article will review current knowledge concerning the effects of known posttranslational modifications upon the molecular chaperone properties and aggregation behavior of alpha-A and alpha-B crystallin. Based upon these effects, experimental approaches will be discussed that may be useful in the development of reagents that may selectively inhibit the cataractogenic process in the aging human lens. |
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