Distribution of herpes simplex virus DNA in the brains of human long-term survivors of encephalitis |
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Authors: | JA Nicoll S Love E Kinrade |
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Affiliation: | A.N. Belozersky Institute of Physico-Chemical Biology, Moscow State University, Russia. |
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Abstract: | The influence of morphine on proliferation of human tumor K562 and lymphoid cells was studied and compared with that on the mitogen-induced proliferation of human peripheral blood mononuclear cells (PBMC). Morphine was shown to act as a suppressor of both cellular DNA synthesis (50% and more as compared to control) and the cellular population growth of mitogen-induced PBMC, B-lymphoma Namalva cells and EBV-transformed lymphocytes. Morphine activated proliferation of myeloid K562 and T-lymphoma Yurkat cells 1.5-fold. It is supposed that the opposite effects of morphine on proliferation of cell lines of immune origin reveal the difference in modulation of diverse immune cell types by morphine. |
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