Insight into solute-solute and solute-solvent interactions of semicarbazide hydrochloride in water and D-glucose/D-sucrose+water solutions at temperatures (293.15 to 318.15) K |
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Authors: | Ankita Dinesh Chand Anil Kumar Nain |
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Affiliation: | 1.Department of Chemistry, Dyal Singh College, University of Delhi, New Delhi 110003, India;2.Department of Chemistry, University of Delhi, Delhi 110007, India;3.Department of Chemistry, Amity University Dubai Campus, Dubai International Academic City, Dubai, UAE |
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Abstract: | The solute-solute and solute-solvent interactions of drug semicarbazide hydrochloride with carbohydrates (D-glucose/D-sucrose) are investigated by using volumetric, viscometric and acoustic properties. The measurements of the densities ρ, ultrasonic speeds u, and viscosities η. of semicarbazide hydrochloride in 5% and 10% D-glucose/D-sucrose+water (w/w) solutions were carried out at temperatures (293.15-318.15) K and at pressure, p=101 kPa. The apparent molar volumes, Vϕ, limiting apparent molar volumes,Vϕ°, apparent molar compressibilities, Ks, ϕ, limiting apparent molar compressibilities, Ks,ϕ°, partial molar expansibilities, Eϕ°, transfer volumes, Vϕ,tr° and transfer compressibilities, Ks,ϕ,tr° have been calculated from the experimental data. The viscosity data were examined by using the Jones-Dole equation and the viscosity A and B coefficients were evaluated. The results are discussed in terms of solute-solute and solute-solvent interactions in these solutions. The structure making/breaking ability of semicarbazide hydrochloride is examined using the sign of temperature derivative of B-coefficient, dB/dT. |
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