Thermal Analysis of Sulphamethoxazole - Sugar Physical Mixes |
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Authors: | James L Ford Monica M Francomb |
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Affiliation: |
a School of Pharmacy Liverpool Polytechnic, Byrom Street, Liverpool, United Kingdom |
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Abstract: | Differential scanning calorimetry and hot stage microscopy have been used to study the interactions between sulphamethoxazole and the sugars maltose, glucose, sucrose and mannitol. Only the sulphamethoxazole-mannitol system appeared to be stable and presented a eutectic containing 90.3% sulphamethoxazole. Heats of fusion for sulphamethoxazole, mannitol and their eutectic were 33.4, 73.6 and 39.9 cal g respectively. |
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Keywords: | |
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