| 盐酸阿比朵尔中间体的合成工艺研究 |
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| 引用本文： | 张达盼,张丽娟,张智勇,孟营,王玉玲. 盐酸阿比朵尔中间体的合成工艺研究[J]. 精细化工中间体, 2011, 41(2): 45-47 |
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| 作者姓名： | 张达盼 张丽娟 张智勇 孟营 王玉玲 |
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| 作者单位： | 沈阳药科大学,制药工程学院,辽宁,沈阳,110016 |
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| 摘 要： | 以1,2-二甲基-5-羟基吲哚-3-甲酸乙酯为原料,经酰化、溴代反应得到盐酸阿比朵尔中间体1-甲基-2-溴甲基-5-乙酰氧基-6-溴吲哚-3-甲酸乙酯(3)。采用均匀设计法考察了反应时间、物料配比对合成收率的影响,得到了合成工艺的优化条件。目标化合物的结构经1H NMR确证。总收率为80.3%,该路线简单,适合工业化生产。
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| 关 键 词： | 盐酸阿比朵尔 中间体 均匀设计 工艺改进 |
Improved Synthesis of the Intermediate for Arbidol Hydrochloride |
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| ZHANG Da-pan,ZHANG Li-juan,ZHANG Zhi-yong,MENG Ying,WANG Yu-ling. Improved Synthesis of the Intermediate for Arbidol Hydrochloride[J]. Fine Chemical Intermediates, 2011, 41(2): 45-47 |
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| Authors: | ZHANG Da-pan ZHANG Li-juan ZHANG Zhi-yong MENG Ying WANG Yu-ling |
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| Affiliation: | (School of Pharmaceutical Engineering,Shenyang Pharmaceutical University,Shenyang 110016,China) |
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| Abstract: | 5-Acetoxyl-6-bromide-2-bromomethyl-1-methy-indoles-3-carboxylic acid ethyl ester(3),a key intermediate for the synthesis of arbidol hydrochloride,was synthesized from 1,2-dimethy-5-hydroxyl-1H-indoles-3-carboxylic acid ethyl ester in an overall yield of 80.3%.The reaction conditions were optimized and the target compound was confirmed with 1H NMR. |
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| Keywords: | Arbidol Hydrochlorid intermediates uniform design process improvement |
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