| 3-羟基-4-甲氧基苯甲醛的合成与表征 |
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| 引用本文： | 殷建平,王芳斌,黄可龙,于金刚.3-羟基-4-甲氧基苯甲醛的合成与表征[J].精细化工,2006,23(5):460-462,520. |
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| 作者姓名： | 殷建平 王芳斌 黄可龙 于金刚 |
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| 作者单位： | 中南大学,化学化工学院,湖南,长沙,410083 |
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| 摘 要： | 以对羟基苯甲醛为原料,经溴代、甲基化和水解3步反应合成了异香兰素,改进并优化了合成路线。溴代采用三氯甲烷作为溶剂,在0℃的条件下反应6 h,n(对羟基苯甲醛)∶n(溴素)=1∶1.05;确定了水解反应的最佳条件:氯化亚铜作催化剂,于130℃反应4 h。反应总收率达62%以上。用IR,1HNMR确证了中间体和产物的结构。
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| 关 键 词： | 异香兰素 溴代 甲基化 水解 |
| 文章编号： | 1003-5214（2006）05-0460-04 |
| 收稿时间： | 2005-10-27 |
| 修稿时间： | 2005-10-272005-12-28 |
Synthesis and Characterization of 3-Hydroxy- 4-methoxybenzaldehyde |
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| YIN Jian-ping,WANG Fang-bin,HUANG Ke-long,YU Jin-gang.Synthesis and Characterization of 3-Hydroxy- 4-methoxybenzaldehyde[J].Fine Chemicals,2006,23(5):460-462,520. |
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| Authors: | YIN Jian-ping WANG Fang-bin HUANG Ke-long YU Jin-gang |
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| Abstract: | Starting from p-hydroxybenzaldehyde,isovanillin(3-hydroxy-4-methoxybenzaldehyde) was synthesized by three-step reactions of bromination,methylation and hydrolysis.Bromination was run at 0 ℃ for 6 h with chloroform as solvent and molar ratio of p-hydroxybenaldehyde bromine 1∶1.05.Hydrolysis was carried out with cuprous chloride as catalyst at 130 ℃ for 4 h.The overall yield of the reactions was over 62%.Structures of the product and intermediate compounds were characterized by IR and ~1HNMR. |
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| Keywords: | isovanillin bromination methylation hydrolysis |
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