| 替考拉宁在不同液液萃取体系中分配系数的测定 |
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| 引用本文： | 陈勇,徐志南,金志华,岑沛霖. 替考拉宁在不同液液萃取体系中分配系数的测定[J]. 中国化学工程学报, 2004, 12(4): 493-497 |
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| 作者姓名： | 陈勇 徐志南 金志华 岑沛霖 |
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| 作者单位： | [1]InstituteofBioengineering,DepartmentofChemicalandBiologicalEngineering,ZhejiangUniversity,Hangzhou310027,China [2]DepartmentofChemicalEngineering,UniversitiTeknologiMalaysia,81310UTMSkudai,Johor,Malaysia |
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| 摘 要： | Teicoplanin is one of the macrocyclic glycopeptide antibiotics, which is active against Gram-positive bacteria, and has attracted a lot of attention in the field of chiral separation recently. In this work, the partition coefficients and extraction ratio of teicoplanin in three different solvent systems were studied: conventional extraction, reactive extraction and reverse micelle extraction. With conventional solvent extraction, n-butanol demonstrated high partition coefficient for teicoplanin, but low extraction ratio because of its high solubility in water. Reactive extraction of teicoplanin showed the highest partition coefficient with almost 100% recovery in organic phase when tri-n-octylmethyl ammonium chloride (TOMAC) was used as extractant and pH value was above 5.0. A reverse micelle system, consisted of isooctane 10 mmol-L^-1 TOMAC -t-1% n-octanol, also offered high separation factor for teicoplanin. The results are beneficial for the design of teicoplanin separation and purification process.
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| 关 键 词： | 液-液萃取法 分离系数 TOMAC 胶态离子 |
| 修稿时间： | |
Determination of Teicoplanin A2's Partition Coefficient in Different Liquid-Liquid Extraction Systems |
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| Bin Mat Hanapi,CHEN Yong,Bin Mat Hanapi,Xu Zhinan,Jin Zhihua,Cen Peilin. Determination of Teicoplanin A2's Partition Coefficient in Different Liquid-Liquid Extraction Systems[J]. Chinese Journal of Chemical Engineering, 2004, 12(4): 493-497 |
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| Authors: | Bin Mat Hanapi CHEN Yong Bin Mat Hanapi Xu Zhinan Jin Zhihua Cen Peilin |
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| Affiliation: | Institute of Bioengineering, Department of Chemical and Biological Engineering, Zhejiang University, Hangzhou,310027, China;Department of Chemical Engineering, Universiti Teknologi Malaysia, 81310 UTM Skudai, Johor, Malaysia |
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| Abstract: | Teicoplanin is one of the macrocyclic glycopeptide antibiotics, which is active against Gram-positive bacteria, and has attracted a lot of attention in the field of chiral separation recently. In this work, the partition coefficients and extraction ratio of teicoplanin in three different solvent systemswere studied: conventional extraction, reactive extraction and reverse micelle extraction. With conventional solvent extraction, n-butanol demonstratedhigh partition coefficient for teicoplanin, but low extraction ratio because of its high solubility in water. Reactive extraction of teicoplanin showed the highest partition coefficient with almost 100% recovery in organic phase when tri-n-octylmethyl ammonium chloride (TOMAC) was used as extractant and pH value was above 5.0. A reverse micelle system, consisted of isooctane +10 mmol-L^-1 TOMAC -t-1% n-octanol, also offered high separation factor for teicoplanin. The results are beneficial for the design of teicoplanin separation and purification process. |
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| Keywords: | ticoplanin partition coefficients conventional extraction reverse micelle extraction |
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