光滑球拟酵母发酵生产丙酮酸

丙酮酸是一种重要的有机酸 ,广泛应用于制药、日化、农用化学品和食品等工业中。相对于化工法生产的丙酮酸而言 ,发酵法生产的丙酮酸具有低成本、高质量等优势。考虑到球拟酵母属的多重维生素营养缺陷型菌株是目前发酵法生产中最常用和最具竞争力的生产菌株 ,因此重点介绍了发酵法生产丙酮酸在菌种、发酵条件优化等方面的研究进展 ,并给出了发酵法将来可能的发展方向。

Production of Pyruvic Acid by Torulopsis Glabrata

Pyruvic acid, an important organic acid, is widely used in the industries of pharmaceuticals, chemicals, agrochemicals, food additives and so on. Compared with the chemical method, biotechnological production of pyruvic acid is an alternative approach because of its low cost and high product quality. In this article, biosynthesis of pyruvic acid, including direct fermentative production and resting cell method as well as enzymatic method, was discussed. Furthermore, a comparison of these different methods was proposed. Since, a multi vitamin auxotrophic strain of Torulopsis glabrata is the most competitive strain for industrial production of pyruvate, emphasis was therefore placed on the development of strains screening and optimization of fermentation conditions. Finally, some suggestions were put forward to improve the research in this field in the near future.