An acryl resin-based swellable microneedles for controlled release intradermal delivery of granisetron |
| |
| Authors: | Guozhong Yang Meilin He Suohui Zhang Man Wu |
| |
| Affiliation: | 1. Key Laboratory of Photochemical Conversion and Optoelectronic Materials, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing, China;2. University of Chinese Academy of Sciences, Beijing, China |
| |
| Abstract: | Swellable microneedles (SMNs) are made of hydrogels and can deliver drug with controlled delivery rate by the cross-link density of the hydrogel. In this study, an acryl resin-based SMNs was developed for poorly water-soluble drugs. The making process of the SMNs is very simple and only need 60?min. The SMNs has high mechanical strength and is not easily broken. In-vitro release of SMNs-loaded model drug, granisetron base (GRB), was investigated. The results showed that seven days controlled release of GRB was obtained when SMNs contained pore-foaming agents (1.5% dicalcium phosphate (CaHPO4) and 1.5% polyvinylpyrrolidone (PVP)). The maximum amount delivered into skin was 86.158?±?7.82% of the initial GRB (2.1?mg) loaded on SMNs preparation. Pharmacokinetics study in rats indicated a dose-dependent profile of plasma GRB concentrations and that the controlled release of 2.1?mg dose was observed for 144?hours. In conclusion, these SMNs provided a potential minimally invasive route for controlled-release systemic delivery of poorly water-soluble drugs. |
| |
| Keywords: | Swellable microneedles granisetron controlled-release poorly water-soluble drugs acrylic resin |
|
|
