| 三乙胺催化合成维生素E琥珀酸单酯的研究 |
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| 引用本文： | 郑燕升,粟晖,李军生. 三乙胺催化合成维生素E琥珀酸单酯的研究[J]. 精细石油化工, 2006, 23(5): 39-41 |
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| 作者姓名： | 郑燕升 粟晖 李军生 |
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| 作者单位： | 广西工学院轻化系,广西,柳州,545006;广西工学院轻化系,广西,柳州,545006;广西工学院轻化系,广西,柳州,545006 |
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| 基金项目： | 国家高技术研究发展计划(863计划);广西高校百名中青年学科带头人项目 |
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| 摘 要： | 以三乙胺为催化剂、维生素E(VE)和琥珀酸酐为原料合成维生素E琥珀酸单酯。采用正交设计法进行工艺优化,并用HPLC法对产物进行分析,优化的反应条件为:丙酮为溶剂,n(VE):n(琥珀酸酐)=1:1．5,催化剂用量0．2 mL,反应时间为8 h,温度为50℃,酯化率可达88．34％,产物纯度>96％。
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| 关 键 词： | 维生素E琥珀酸单酯 合成 三乙胺 酯化反应 |
| 收稿时间： | 2005-08-01 |
| 修稿时间： | 2006-09-12 |
STUDY ON THE CATALYTIC SYNTHESIS OF VITAMIN E SUCCINATE BY TRIETHYL AMINE |
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| Zheng Yansheng,Su Hui,Li Junsheng. STUDY ON THE CATALYTIC SYNTHESIS OF VITAMIN E SUCCINATE BY TRIETHYL AMINE[J]. Speciality Petrochemicals, 2006, 23(5): 39-41 |
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| Authors: | Zheng Yansheng Su Hui Li Junsheng |
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| Affiliation: | Department of Biological and Chemical Engineering, Guangxi University of Technology, Liuzhou 545006, Guangxi, China |
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| Abstract: | Catalyzed by triethyl amine, vitamin E succinate was synthesized with vitamin E and succin-ic anhydride. Through orthogonal experiments and the vitamin E succinate product was analysed by HLCP. The optimal conditions were found as follows: propanone as solvent, the molar ratio of vitamin E to succinc anhydride = 1 : 1. 5, 0. 2 mL catalyst, reaction time 8 h and reaction temperature 50℃. Under these conditions, the conversion of vitamin E was 88. 34% and the purity of the product was above 96%. |
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| Keywords: | vitamin E succinate synthesis triethyl amine esterification |
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