| 一锅法合成苯基苄基甲酮 |
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| 引用本文： | 刘明星,糜志远,张迎庆,邹群,李莉. 一锅法合成苯基苄基甲酮[J]. 化学试剂, 2005, 27(12): 759-760 |
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| 作者姓名： | 刘明星 糜志远 张迎庆 邹群 李莉 |
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| 作者单位： | 湖北工业大学,生物工程学院,湖北,武汉,430068;湖北工业大学,生物工程学院,湖北,武汉,430068;湖北工业大学,生物工程学院,湖北,武汉,430068;湖北工业大学,生物工程学院,湖北,武汉,430068;湖北工业大学,生物工程学院,湖北,武汉,430068 |
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| 基金项目： | 湖北工业大学校青年基金（QN200312）;湖北省教育厅青年基金（2004Q001）资助项目. |
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| 摘 要： | 以苯乙氰和苯甲酸甲酯为起始原料,在碱性条件下,采用Claisen缩合合成中间产物苯基-1-氰基苄基甲酮,不经分离,直接在48%氢溴酸水溶液中水解脱羧得到苯基苄基甲酮,产率为92.3%.用质谱、核磁和红外等波谱鉴定了目标分子的结构.该法反应条件温和,产率高,原料易得,操作简单.
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| 关 键 词： | 苯基苄基甲酮 Claisen缩合 苯基-1-氰基苄基甲酮 一锅法 合成 |
| 文章编号： | 0258-3283（2005）12-0759-02 |
| 收稿时间： | 2005-03-27 |
| 修稿时间： | 2005-03-27 |
One-pot synthesis of phenyl benzyl ketone |
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| LIU Ming-xing,MI Zhi-yuan,ZHANG Ying-qing,ZOU Qun,LI Li. One-pot synthesis of phenyl benzyl ketone[J]. Chemical Reagents, 2005, 27(12): 759-760 |
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| Authors: | LIU Ming-xing MI Zhi-yuan ZHANG Ying-qing ZOU Qun LI Li |
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| Affiliation: | Institute of Bioengineering, Hubei University of Technology, Wuhan 430068, China |
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| Abstract: | Phenyl benzyl ketone was prepared from phenylacetonitrile and benzoic acid methyl ester. In the reaction process, the intermediate phenyl-1-nitrilebenzylketone obtained by Claisen condensation in basic condition was not separated from the reaction mixture, but used directly to synthesize the targeting molecule by hydrolyzing in 48 % HBr solution. The yield was 92.3 % . The targeting compound was characterized by MS, ^1HNMR and FTIR. The method had some advantages of gentle reaction conditions, high yield, cheap raw materials and simple operation. |
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| Keywords: | phenyl benzyl ketone Claisen condensation phenyl-1-nitrilebenzylketone one-pot method synthesis |
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