| 离子液体催化2-氯噻吩氯甲基化反应研究 |
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| 引用本文： | 张金玲,方岩雄.离子液体催化2-氯噻吩氯甲基化反应研究[J].精细化工,2010,27(8). |
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| 作者姓名： | 张金玲 方岩雄 |
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| 作者单位： | 广东工业大学轻工化工学院,广东广州,510006 |
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| 基金项目： | 国家自然基金资助项目，广东省基金资助项目，广州市科技计划 |
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| 摘 要： | 以2-氯噻吩、多聚甲醛为原料,以离子液体C2mim]Br、C3mim]Br、C4mim]Br、C5mim]Br、C6mim]Br、C7mim]Br、C8mim]Br、C12mim]Br、Bmim]PF6、Bmim]BF4、Bmim]C4F9SO3和Bmim]Cl为催化剂进行氯甲基化反应,得到产物2-氯-3-氯甲基噻吩。研究表明,离子液体可以促进2-氯噻吩的氯甲基化反应,具有相转移催化剂的效果,并且以C4mim]Br和C8mim]Br的催化效果为佳。反应最佳条件为:离子液体C8mim]Br摩尔分数为5%(相对于2-氯噻吩),温度40℃,反应时间8h,产物产率可达92.1%。
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| 关 键 词： | 离子液体 2-氯噻吩 2-氯-3-氯甲基噻吩 氯甲基化 医药与日化原料 |
| 收稿时间： | 2010/3/29 0:00:00 |
| 修稿时间： | 2010/5/20 0:00:00 |
Study on Chloromethylation of 2-chloro-thiophene Catalyzed by Ionic Liquids |
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| ZHANG Jin-ling and FANG Yan-xiong.Study on Chloromethylation of 2-chloro-thiophene Catalyzed by Ionic Liquids[J].Fine Chemicals,2010,27(8). |
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| Authors: | ZHANG Jin-ling and FANG Yan-xiong |
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| Affiliation: | Faculty of Chemical Engineering and Light Industry, Guangdong University of Technology,Faculty of Chemical Engineering and Light Industry, Guangdong University of Technology |
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| Abstract: | The chloromethylation of 2-chloro-thiophene and paraformaldehyde to 2-chloro-3-chloromethyl-thiophene in the catalysis of different ionic liquids,C2mim]Br,C3mim]Br,C4mim]Br,C5mim]Br,C6mim]Br,C7mim]Br,C8mim]Br,C12mim]Br,Bmim]PF6,Bmim]BF4,Bmim]C4F9SO3 and Bmim]Cl was investigated.Result showed that as a phase transfer catalyst ionic liquid could promote the chloromethylation of 2-chloro-thiophene.C4mim]Br and C8mim]Br had the best catalytic activity.The influence factors,such as the dosage of catalyst,reaction temperature,reaction time and the amount of paraformaldehyde were discussed.Under the best conditions,the dosage of catalyst C8mim]Br was 5%,40 ℃,8 h,a good yield was obtained in 92.1%. |
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| Keywords: | ionic liquid 2-chloro-thiophene 2-chloro-3-chloromethyl-thiophene chloromethylation drug and cosmetic materials |
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