| 3-氨基吡唑-4-甲酰胺半硫酸盐的合成 |
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| 引用本文： | 丁敬敏,陈绘如,张文雯,陈闻起.3-氨基吡唑-4-甲酰胺半硫酸盐的合成[J].应用化工,2009,28(1). |
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| 作者姓名： | 丁敬敏 陈绘如 张文雯 陈闻起 |
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| 作者单位： | 常州工程职业技术学院,应用化学技术系,江苏,常州,213164 |
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| 摘 要： | 以原甲酸三乙酯、丙二腈为起始原料,合成乙氧亚甲基丙二腈(Ⅰ),将其加入80%水合肼中,加热回流,生成3-氨基-4-甲酰胺吡唑(Ⅱ),将其与浓硫酸混合,调节pH值,40℃下搅拌0.5 h,经过滤,重结晶,得到目标化合物3-氨基吡唑-4-甲酰胺半硫酸盐(Ⅲ),总收率63.7%(以丙二腈计)。目标化合物结构经红外光谱、核磁共振分析验证。
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| 关 键 词： | 3-氨基吡唑-4-甲酰胺半硫酸盐 别嘌醇 合成 |
Synthesis of 3-amino-4-pyrazolecarboxamide hemisulfate |
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| DING Jing-min,CHEN Hui-ru,ZHANG Wen-wen,CHEN Wen-qi.Synthesis of 3-amino-4-pyrazolecarboxamide hemisulfate[J].Applied chemical industry,2009,28(1). |
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| Authors: | DING Jing-min CHEN Hui-ru ZHANG Wen-wen CHEN Wen-qi |
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| Abstract: | Malononitrile was treated with ethyl orhoformate to give intermediate ethoxymethylenemalononitrile(Ⅰ),(Ⅰ) was added in 80% hydrazine hydrate and the mixture was stirred at reflux temperature to afford 3-amino-4-pyrazolecarboxamide(Ⅱ).Compound Ⅱ was mixed with sulfuric acid and stirred for 5 h at 40 ℃.By filtration and recrystallization,the target compound of 3-amino-4-pyrazolecarboxamide hemisulfate(Ⅲ) was obtained.The total yield is 63.7%(based on malononitrile).The structure of target compound was confirmed by analysis of IR and 1H NMR. |
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| Keywords: | 3-amino-4-pyrazolecarboxamide hemisulfate allopurinol synthesis |
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