Cytokine responses of human lung cells (BEAS-2B) treated with micron-sized and nanoparticles of metal oxides compared to soil dusts |
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| Authors: | John M Veranth Erin G Kaser Martha M Veranth Michael Koch Garold S Yost |
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| Affiliation: | (1) Department of Pharmacology and Toxicology, University of Utah, Salt Lake City, Utah, USA |
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| Abstract: | Background The induction of cytokines by airway cells in vitro has been widely used to assess the effects of ambient and occupational particles. This study measured cytotoxicity and the
release of the proinflammatory cytokines IL-6 and IL-8 by human bronchial epithelial cells treated with manufactured nano-
and micron-sized particles of Al2O3, CeO2, Fe2O3, NiO, SiO2, and TiO2, with soil-derived particles from fugitive dust sources, and with the positive controls LPS, TNF-α, and VOSO4. |
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