Comparison of a static and a dynamic in vitro model to estimate the bioaccessibility of As, Cd, Pb and Hg from food reference materials Fucus sp. (IAEA-140/TM) and Lobster hepatopancreas (TORT-2) |
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Authors: | Torres-Escribano Silvia Denis Sylvain Blanquet-Diot Stéphanie Calatayud Marta Barrios Laura Vélez Dinoraz Alric Monique Montoro Rosa |
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Affiliation: | a Instituto de Agroquímica y Tecnología de Alimentos (IATA-CSIC), Apdo. 73, 46100, Burjassot, Valencia, Spainb Clermont Université, Université d'Auvergne, Centre de Recherche en Nutrition Humaine Auvergne, ERT 18, Conception ingénierie et développement de l'aliment et du médicament, BP 10448, F-63000 Clermont-Ferrand, Francec Departamento de Informática Científica (SGAI-CSIC), C/ Pinar 19, 28006 Madrid, Spain |
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Abstract: | Bioaccessibility, the fraction of an element solubilized during gastrointestinal digestion and available for absorption, is a factor that should be considered when evaluating the health risk of contaminants from food. Static and dynamic models that mimic human physiological conditions have been used to evaluate bioaccessibility. This preliminary study compares the bioaccessibility of arsenic (As), cadmium (Cd), lead (Pb) and mercury (Hg) in two food certified reference materials (CRMs) (seaweed: Fucus sp., IAEA-140/TM; Lobster hepatopancreas: TORT-2), using two in vitro gastrointestinal digestion methods: a static method (SM) and a dynamic multicompartment method (TIM-1). There are significant differences (p < 0.05) between the bioaccessible values of As, Cd, Pb and Hg obtained by SM and TIM-1 in the two CRMs. The specific form in which the elements studied are present in the CRM may help to explain the bioaccessibility values obtained. |
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Keywords: | Arsenic Cadmium Lead Mercury Bioaccessibility In vitro gastrointestinal digestion models |
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