Behavioral and morphologic disorders caused by bilateral photoinduced thrombosis of the cerebral vessels of the frontal cortex in rats

Chronic experiments were made on 35 non-inbred male rats (200-250 g b.w.) to study functional and morphological consequences of photochemical thrombosis of frontal cortex vessels Defects in CNS function were assessed by conditioned reflexes of passive avoidance and behavior in open field tests. The size of the ischemic focus and perifocal lesion were measured on the stained histological sections. Correction of the postischemic impairment was done by intraperitoneal injection of a new nootrop--ethyl ether of N-phenylacetylprolylglycine (GVS-111)--in a dose 0.8 mg/kg/day. The results of the experiments show a significant neuroprotective and nootropic action of GVS-111 in focal ischemic brain damage.