| 复合诱变法筛选FK506高产菌株 |
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| 引用本文： | 王秀琴,王晓蕾,蒋沁.复合诱变法筛选FK506高产菌株[J].河北化工,2010,33(3):30-31. |
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| 作者姓名： | 王秀琴 王晓蕾 蒋沁 |
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| 作者单位： | 华北制药集团新药研究开发有限责任公司微生物药物国家工程研究中心,河北石家庄,050015 |
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| 摘 要： | 通过复合诱变的方法对出发菌株筑波链霉菌08-6—9进行处理，得到一株FK506高产菌株08-9-81，其摇瓶发酵水平较出发菌株提高73．6％，并顺利通过20L发酵罐放大，具有实际生产意义。
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| 关 键 词： | FK 506 亚硝基胍 复合诱变 |
Screening of High FK 506-Producing Strain by Combined Mutation |
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| FANG Xiu-qin,FANG Xiao-lei,JIANG Qin.Screening of High FK 506-Producing Strain by Combined Mutation[J].Hebei Chemical Engineering and Industry,2010,33(3):30-31. |
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| Authors: | FANG Xiu-qin FANG Xiao-lei JIANG Qin |
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| Affiliation: | (National Engineering Research Center of Microbial Medicine, New Drug R ＆ D Co..Ltd of North China Pharmacentical Corp, Shijiazhuang 050015,China) |
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| Abstract: | Combined mutation was used to treat the original strain streptomyces tsukubaensis 08-6-9, a high FK 506-producing strain 08-9-81 was obtained, the FK 506 productivity of which was further improved by 73.6% than the original strain in shaking culture, it was successfully used in scaling up in 20 L bioreactor, which was significant in realistic production. |
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| Keywords: | FK 506 |
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