| 卵磷脂改性磁性碳纳米管的制备及生物相容性 |
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| 引用本文： | 毕利顺,王宗花,夏建飞,张菲菲,夏延致,李延辉. 卵磷脂改性磁性碳纳米管的制备及生物相容性[J]. 复合材料学报, 2012, 29(3): 117-121 |
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| 作者姓名： | 毕利顺 王宗花 夏建飞 张菲菲 夏延致 李延辉 |
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| 作者单位： | 化学化工与环境学院, 国家重点实验室培育基地, 纤维新材料与现代纺织实验室, 青岛 266071 |
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| 基金项目： | 国家自然科学基金，青岛市科技计划基础研究项目，NSFC-JSPS中日合作与交流项目，山东省自然科学基金，山东省泰山学者资助项目 |
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| 摘 要： | 采用生物活性两亲性分子卵磷脂(PC), 对制备的磁性碳纳米管(Fe3O4/CNTs)进行非共价修饰, 得到了内部为疏水端、外部为带电亲水基团的类膜结构包覆的改性复合材料Fe3O4/CNTs-PC。在溶液中带电基团通过溶剂化作用及亲水作用, 在复合材料表面形成水化层, 提高复合材料的自由水含量。在蛋白质吸附实验与复钙化凝血时间评价中, Fe3O4/CNTs-PC对蛋白质吸附量仅为0.1368 mg/mg, 复钙化凝血时间延长至324 s, 具有很好的生物相容性。
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| 关 键 词： | 卵磷脂 磁性碳纳米管 功能化 非共价 生物相容性 蛋白质吸附 抗凝血 |
| 收稿时间： | 2011-08-25 |
Preparation and biocompatibility of phosphatidylcholine modified magnetic carbon nanotubes |
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| BI Lishun,WANG Zonghua,XIA Jianfei,ZHANG Feifei,XIA Yanzhi,LI Yanhui. Preparation and biocompatibility of phosphatidylcholine modified magnetic carbon nanotubes[J]. Acta Materiae Compositae Sinica, 2012, 29(3): 117-121 |
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| Authors: | BI Lishun WANG Zonghua XIA Jianfei ZHANG Feifei XIA Yanzhi LI Yanhui |
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| Affiliation: | Laboratory of Fiber Materials and Modern Textile, The Growing Base for State Key Laboratory, College of Chemical and Environmental Engineering, Qingdao University, Qingdao 266071, China |
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| Abstract: | A kind of biomimetic amphoteric polymer,phosphatidylcholine(PC),was used as surfactant to produce water soluble and biocompatible magnetic carbon nanotubes(Fe3O4/CNTs),which was prepared by solvothermal method.Fe3O4/CNTs was facilely dispersed in aqueous media by ultrasonication with the help of PC,with the long hydrophobic segment and the hydrophilic group as controls.The biological properties of the PC modified Fe3O4/CNTs(Fe3O4/CNTs-PC) were evaluated using protein adsorption assay and recalcification time.The results indicate that the adsorption capacity of bovine serum albumin(BSA) is 0.1368 mg/mg,and the recalcification time is 324 s.These experimental results suggest that Fe3O4/CNTs-PC has good outstanding biocompatibility. |
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| Keywords: | phosphatidylcholine(PC) magnetic carbon nanotubes functionalization noncovalent biocompatibility~protein adsorption~ anticoagulation |
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