| 异十异戊二烯醇的合成 |
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| 引用本文： | 陈田,杨运泉,周国平,刘文英.异十异戊二烯醇的合成[J].化学试剂,2007,29(12):753-755. |
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| 作者姓名： | 陈田 杨运泉 周国平 刘文英 |
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| 作者单位： | 湘潭大学,化工学院,湖南,湘潭,411105 |
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| 基金项目： | 湖南省科技厅科技攻关项目 |
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| 摘 要： | 以茄尼醇为原料,吡啶为催化剂,在石油醚中与PBr3反应得到茄尼基溴,收率90%;然后将其溶于石油醚中与乙酰乙酸甲酯反应,采用无水碳酸钾作为碱,碘化四正丁基铵(TBAI)为相转移催化剂,得到的中间产物在碱性条件下酮式分解得到茄尼基丙酮,收率90%;再在氮气保护下与溴乙烯镁格氏试剂反应,得到标题化合物,收率75%。通过熔点I、R、1HNMR验证了化合物的结构,与文献报道一致。
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| 关 键 词： | 异十异戊二烯醇 辅酶Q10 茄尼醇 茄尼基溴 茄尼基丙酮 合成 |
| 文章编号： | 0258-3283（2007）12-0753-03 |
| 收稿时间： | 2007-06-26 |
| 修稿时间： | 2007年6月26日 |
Synthesis of iso-decaprenol |
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| CHEN Tian,YANG Yun-quan,ZHOU Guo-ping,LIU Wen-ying.Synthesis of iso-decaprenol[J].Chemical Reagents,2007,29(12):753-755. |
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| Authors: | CHEN Tian YANG Yun-quan ZHOU Guo-ping LIU Wen-ying |
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| Abstract: | iso-Decaprenol,the side chain of Miracle Nutrient coenzyme Q10,is synthesized from the starting material solanesol.Bromination of solanesol by PBr3 produced solanesyl bromide in 90% yield,which further entered into reaction with methyl aceto-acetate in petroleum ether to yield an intermediate.This intermediate was transformed to solanesyl acetone in 90% yield in the presence of TBAI as the phase transfer catalyst and using K2CO3 as the alkali.Solanesyl acetone entered into reaction with vinyl-magnesium bromide under N2 to yield iso-decaprenol in 75% yield.The structures of all products were confirmed by IR and 1HNMR. |
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| Keywords: | iso-decaprenol coenzyme Q10 solanesol solanesyl bromide solanesylacetone synthesis |
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