Strong resistance of poly (ethylene glycol) based L‐tyrosine polyurethanes to protein adsorption and cell adhesion |
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| Authors: | Jui‐Chen Yang Chao Zhao I‐Fan Hsieh Senthilram Subramanian Lingyun Liu Gang Cheng Lingyan Li Stephen Z. D. Cheng Jie Zheng |
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| Affiliation: | 1. Department of Chemical and Biomolecular Engineering, University of Akron, Akron, OH 44325, USA;2. Department of Polymer Science, University of Akron, Akron, OH 44325, USA |
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| Abstract: | Biofouling that involves protein adsorption, cell and bacteria adhesion, and biofilm formation between a surface and biological entities is a great challenge for biomedical and industry applications. In this work, L ‐tyrosine‐derived polyurethanes (L ‐polyurethane) with different molecular weights of poly(ethylene glycol) (PEG) were synthesized, characterized and coated on gold surfaces using spin‐coating. The non‐fouling activity of different L ‐polyurethane films was evaluated by protein adsorption and cell adhesion. Surface plasmon resonance and cell assay results demonstrate that the PEG content in these L ‐polyurethanes contributes excellent resistance to protein adsorption and cell attachments. This work provides alternative and effective biomaterials for potential applications in blood‐contacting devices. Copyright © 2011 Society of Chemical Industry |
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| Keywords: | antifouling polyurethane poly(ethylene glycol) surface resistance |
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