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Alginate grafted with poly(ε‐caprolactone): effect of enzymatic degradation on physicochemical properties |
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| Authors: | Samir Benykhlef Virginie Dulong Zohra Bengharez Luc Picton Kaddour Guemra Didier Le Cerf |
| Affiliation: | 1. Université de Rouen, Laboratoire Polymères, Biopolymères, Surfaces, CNRS‐UMR 6270 & FR3038, 76821 Mont Saint Aignan, France;2. Laboratoire de Chimie Organique, Physique et Macromoléculaire, Faculté des Sciences, BP 89, Université de Sidi Bel Abbès, 22000 Sidi Bel Abbès, Algeria;3. Université de Mascara, BP 305, Route de Mamounia, 29000 Mascara, Algeria |
| Abstract: | The paper discusses the enzymatic behaviour of a series of copolymers composed of alginate grafted with poly(ε‐caprolactone) (PCL) of various lengths and degrees of substitution. The study is focused on viscosity measurements and pyrene probe fluorescence with or without two enzymes: alginate lyase, which breaks the alginate backbone; and esterase, which breaks PCL pendent groups. Alginate lyase is inactive at pH = 3.8 and degrades quickly all copolymers at pH = 6.3. The degradation is not complete and is slowed down by the presence of PCL. Esterase degrades only copolymers with long pendent PCL groups. It has no effect on copolymers when PCL has a length of 530 g mol?1. These systems are good candidates for controlled release of drugs using an enzymatic method. Copyright © 2012 Society of Chemical Industry |
| Keywords: | block copolymer enzymatic treatment polysaccharide PCL |