Experimental study on effect of shenyi xieli mixture on nature killer cell activity and lymphocyte reactivity to IL-2 in tumor mice

OBJECTIVE: To explore therapeutic mechanism of Shengyi Xieli Mixture (SYXLM) on malignant tumor. METHODS: Chemotherapy, radiotherapy and different doses of SYXLM were used to treat tumor mice correction of rats]. RESULTS: SYXLM could enhance the nature killer (NK) cell activities of the tumor mice correction of rats], and this effect was dose dependent (control group 52.70 +/- 6.01, SYXLM No. 1 group 59.01 +/- 10.00, SYXLM No. 2 group 78.33 +/- 10.90, P < 0.01). The NK cell activities of the tumor mice correction of rats] were inhibited in the chemotherapy group alone, but they were enhanced in the group of chemotherapy combined with SYXLM (P < 0.05), the results were the same in the radiotherapy group alone and the group of radiotherapy combined with SYXLM (P < 0.05). The response of lymphocyte of the tumor mice correction of rats] to IL-2 was enhanced significantly in SYXLM group compared with the control group. This response was enhanced insignificantly in the group in which radiotherapy combined with the SYXLM. CONCLUSION: The SYXLM could enhance the function of immune system of the tumor mice correction of rats] and diminish or reduce the side effect of radiotherapy, chemotherapy to the immune system of the tumor mice correction of rats].